GATE BT Immunology PYQs & Answers — Page 3

Questions 21–27 of 27. Imported answers require independent review unless marked reviewed.

Which one of the combinations of the following statements is true about antibody structure?

P. Limited proteolysis of rabbit IgG with the enzyme pepsin generates two antigen-binding regions (Fab) and an Fc fragment Q. Limited proteolysis of rabbit IgG with the enzyme papain generates a single bivalent antigen-binding region F(ab′)₂ and peptide fragments R. The Fc fragment of IgG can self-associate and crystallize into a lattice S. The F(ab′)₂ fragment of IgG is composed of both light and heavy chains

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P and Q only

P and R only

R and S only

Q and S only

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Which one of the following statements is true with regard to processing and presentation of protein antigens?

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In the class II MHC pathway, protein antigens in the cytosol are processed by proteases

In the class I MHC pathway, extracellular protein antigens are endocytosed into vesicles and processed

In the class I MHC pathway, transporter associated antigen processing (TAP) protein is required for translocating processed peptides generated in the cytosol

Invariant chain in endoplasmic reticulum is involved in transport of peptides and loading of class I MHC

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Which one of the following mechanisms is used by human pathogens to evade host immune responses?

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Somatic hypermutation

Antibody production

Antigenic variation

Complement activation

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Enzyme-linked immunosorbent assay (ELISA) is used for

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quantifying antibody levels in blood

determining the molecular weight of an antigen

purifying proteins from biological fluids

determining the molecular weight of an antibody

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Macrophages eliminate pathogenic bacteria upon activation by

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NK cells

basophils

CD4+ T cells

plasma cells

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An immunocompetent person becomes infected with a pathogenic strain of bacteria. Which one of the following graphs correctly depicts bacterial load in this person over time?

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Diagram for Biotechnology question 40 (figure 2)

Diagram for Biotechnology question 40 (figure 3)

Diagram for Biotechnology question 40 (figure 4)

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Which of the following conditions promote the development of human autoimmune disorders?

P. Inability to eliminate self-reactive lymphocytes Q. Generation of auto-antibodies R. Ability to eliminate self-reactive T-cells S. Induction of regulatory T-cells in the thymus

Your answerChoose one option.

P, R

Q, S

P, Q

R, S

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GATE BT Immunology PYQs

Question 32

Question 33

Question 7

Question 12

Question 13

Question 40

Question 55