GATE XL Gene expression in Eukaryotes PYQs & Answers

Questions 1–10 of 12. Imported answers require independent review unless marked reviewed.

Which one of the following describes the role of enhancers in eucaryotic gene regulation?

Your answerChoose one option.

Enhancers always lie immediately upstream of the promoter and function only in a fixed orientation

Enhancers can act at variable distances from the promoters and may function upstream, downstream, or within introns of genes

Enhancers directly bind to RNA polymerase II to initiate transcription

Enhancers overlap with the RNA polymerase II binding site

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A drug was developed to inhibit histone acetyl transferase in eukaryotic cells. Cells treated with this drug have more compact chromatin and show reduction in transcription of several genes. Which one of the following statements best explains why the drug has this effect?

Your answerChoose one option.

Histone acetylation increases positive charge on histones, thereby tightening DNA binding and repressing transcription

Histone H1 directly binds the nucleosome core and its acetylation directly causes nucleosome disassembly

Histone acetylation neutralizes positive charge on histones, thereby loosening DNA-histone interactions and promoting transcription

Euchromatin is normally condensed, so reduced acetylation of histones converts it into a transcriptionally active state

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A PCR was setup to amplify a 500 nucleotides-long DNA. The dNTPs in the reaction mixture were labeled. The percentage (%) of radiolabeled single-stranded DNA after three cycles will be ______ (up to one decimal place)

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Match the molecules in Column-I with their correct property/function in Column-II.

Column-I: P. RNase P; Q. RNA Polymerase-I; R. siRNA; S. Guide RNA

Column-II: 1. rRNA gene transcription; 2. Gene silencing; 3. Cas9-mediated genome editing; 4. Ribozymes; 5. tRNA gene transcription

Your answerChoose one option.

P–4; Q–5; R–2; S–3

P–5; Q–1; R–3; S–4

P–4; Q–1; R–2; S–3

P–1; Q–3; R–4; S–2

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Nucleosomes are made up of DNA and histones. Histones undergo various kind of modifications by different groups of proteins. They are known as histone writers, readers and erasers. Which of the following is/are histone writer(s)?

Your answerSelect all correct options. You can choose more than one.

Histone acetyl transferases

Histone methyl transferases

Histone deacetylases

DNA methyl transferases

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The expression of a gene is regulated by a transcription factor. Which of the following techniques can be used to identify the region in its promoter where the transcription factor binds?

Your answerSelect all correct options. You can choose more than one.

S1 nuclease mapping

Chromatin immunoprecipitation followed by sequencing

Electrophoretic mobility shift assay

DNase I footprinting

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Which one of the following statements about gene expression is INCORRECT?

Your answerChoose one option.

DNA is transcribed to mRNA.

mRNA can be reverse-transcribed to DNA.

mRNA can be translated to protein.

Protein can be reverse-translated to mRNA.

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Codon bias is correlated with the relative frequencies of which one of the following types of RNA?

Your answerChoose one option.

mRNA

rRNA

siRNA

tRNA

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CREB1 is a eukaryotic transcription factor. In which one of the following compartments of the cell is CREB1 predominantly localized?

Your answerChoose one option.

lysosomes

mitochondria

nucleus

peroxisomes

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In Drosophila melanogaster, a mutation in Ultrabithorax which defines the third segment of the thorax or T3 leads to development of four wing flies, as the halteres develop into a second pair of wings. Which ONE of the following phenotypes in fly will result from overexpression of Ultrabithorax in the second thoracic segment?

Your answerChoose one option.

Four winged flies.

Two wings and two halteres flies.

Flies with four halteres.

Flies with two halteres.

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GATE XL Gene expression in Eukaryotes PYQs

How to practice Gene expression in Eukaryotes

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Question 13