GATE XL 2019 Paper 1 — page 35

Questions 103–105 of 125. Imported answers require review unless explicitly marked reviewed.

An enzyme that follows Michaelis-Menten kinetics catalyses the conversion of 35 μM substrate into product with a reaction velocity of 10 μM s⁻¹. The Kₘ and kₐₜ for the substrate are 14 μM and 500 s⁻¹ respectively. The total amount of enzyme taken for the enzyme reaction is ____ nM.

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A distinctly large population of randomly mating laboratory mice contains 36% albino mice, which is caused by a double recessive genotype (aa). The black coloured mice in the population is due to dominant genotype (AA/Aa). Considering the fact that this population is in Hardy-Weinberg equilibrium, the frequency of heterozygous alleles (Aa) in this population is _____ (round off to 2 decimal places).

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A genetic cross was made between homozygous wild-type males (a⁺b⁺c⁺) and triple-mutant females (abc) of Drosophila melanogaster. Then the F₁ males (a⁺b⁺c⁺) were back crossed to the triple-mutant females which resulted in the following F₂ progenies:

Progeny	Number
a⁺bc	16
ab⁺c	115
abc	311
a⁺b⁺c	64
ab⁺c⁺	61
a⁺b⁺c⁺	317
a⁺bc⁺	99
ab c⁺	17
Total	1000

The order of genes as determined from the above data was found to be “b a c” (note that the order is equivalent to “c a b” and the order of outside markers are arbitrary).

The map distance between “b and c” is _____ centiMorgan (round off to 1 decimal place).

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2019 · Paper 1

Question 18

Question 19

Question 20